According to a scientific study, double doses of Sputnik V provide higher Geometric Mean Titers of virus-neutralizing antibodies to the Omicron variant of Covid than two doses of the Pfizer vaccine. The study was conducted in Spallanzani Institute in the equal laboratory conditions at the Italian Spallanzani Institute on comparable groups of sera from individuals vaccinated with Sputnik V and Pfizer, with no statistically significant difference in neutralizing activity against the Wuhan variant.
Currently, swiftly spreading Omicron sub-variants BA.4 and BA.5 are causing surges of positive cases in the US, South Africa, and 70 other countries. Studies said that the Sputnik V vaccine provides for eliciting high titers of virus-neutralizing antibodies to the Omicron variant. The use of native S glycoprotein and the use of a heterologous prime-boost vaccination regimen are the advantages of Sputnik V.
The Pfizer vaccine uses the spike protein in a proline-stabilized form in contrast to Sputnik V. Proline-stabilisation and other changes may move an immune response predominantly to the actively mutating receptor-binding domain of spike protein. Stronger protection against Omicron and other variants is provided by partnerships between adenoviral and mRNA vaccines.
Heterologous boosting with Sputnik Light is the best solution to increase other vaccines’ efficacy and extend the booster protection period as optimal adenoviral platform configuration offers better protection against Omicron and other mutations.